NMR Backbone Resonance Assignment of TREM2 transmembrane helix K186A variant

γ-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics.

TREM2 transmembrane helix in complex with the partner protein DAP12

500 uM TREM2-TMH K186A in 300mM DPC
20 mM NaPi pH7.0
50 mM NaCl
0.5 mM EDTA
5 mM DTT