C-SH2 domain of SHP-2 in complex with phospho-ITSM of PD-1

Tyrosine-protein phosphatase non-receptor type 11 (E.C.3.1.3.48), ITSM

(2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid

1H, 13C, 15N chemical shift assignments of SHP2 SH2 domains in complex with PD-1 immune-tyrosine motifs.

simulated annealing-molecular dynamicssimulated annealing-molecular dynamics

800 uM [U-13C; U-15N] C-SH2 domain of SHP-2, 640 uM ITSM, 90% H2O/10% D2O

MES (2-(N-morpholino)ethanesulfonic acid)

SHP-2 C-SH2 ITSM SH2 domain PD-1 phosphotyrosine

Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax

Brunger, Adams, Clore, Gros, Nilges and Read