Human DC-SIGN Carbohydrate Recognition Domain

Globular domain responsible for glycan recognition, that belongs
to the extracelular domain (ECD) of the membrane protein DC-SIGN.

Structure of the same CRD bound to LNFP III

separate tube (no insert) similar to the experimental sample tube

Molecular Insights into DC-SIGN Binding to Self-Antigens: The Interaction with the Blood Group A/B Antigens.

Formula mass (only CRD, no His-tag): 17230

Residues 1-26 (228-253) represent a non-native affinity tag.
Residues 27-177 correspond to residues 254-404 in PDB 1SL5 (CRD domain).

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As explained in the publication, molecular dynamics of the free CRD
complicated the assignment of loop regions through triple resonance.
The CBCACONH and HNCACB experiments were re-acquired in the presence
of D-Mannose to reduce broadening and signal loss.